Effect of antihistamine-containing syrup on salivary metabolites: an in vitro and in vivo study

This study tested the null hypothesis that antihistamine-containing syrup does not change salivary metabolites in vitro and vivo. For experiments, saliva from 10 volunteers was mixed with a or pill suspension of loratadine (1 mg/ml Claritin®, Schering-Plough, Rio de Janeiro, Brazil). vivo experiment, performed mouth rinse mL antihistamine (Claritin®; Brazil) for 20 seconds then discarded water. After seconds, 5 unstimulated whole spit into plastic tube kept on ice. The protein profile experiments analyzed using 12% sodium dodecyl sulfate-polyacrylamide gel electrophoresis. samples were also by nuclear magnetic resonance (NMR) spectroscopy, followed Principal Component Analysis Wilcoxon test (p < 0.05). There differences after interaction. concentrations acetate, n-caproate, arginine, glutamate, lysine among other reduced both 0.05), but no observed when used > Similar changes metabolite profiles experiments. Electrophoresis revealed difference pattern. rejected because intake medicine composition influences oral homeostasis susceptibility to diseases.